Researchers and physicians have found that antifungal medications are very effective at treating the symptoms of chronic rhinosinusitis (CRS) and in preventing the tissue damage that occurs. These drugs work by either killing the fungus or decreasing its growth. This lessens or prevents the body's immune response that is responsible for symptoms.

Several medications can be used for the treatment of CRS:

• Amphotericin B
• Voriconazaole
• Itraconazole

The medication is available as a solution that is applied directly to the nasal passages and mucus where the fungus is. Therefore it is very effective. Because the medication is not ingested, it also has minimal side effects. Studies in patients with CRS have shown that this treatment is safe and effective.

Clinical Studies

• Intranasal Antifungal Treatment in 51 Patients with Chronic Rhinosinusitis
  Patients in this study were treated with the topical antifungal drug, amphotericin B. The patients were instructed to apply a solution of the drug to their nasal passages twice daily. After being treated for three months or more, 75% of patients had fewer or less severe symptoms. Decreased nasal inflammation also occurred and was seen in visual examination or by CT scans of the sinuses. After treatment, 35% of patients were free from disease and an additional 39% of patients had decreased inflammation.
  
  
• Effect of Anti-Fungal Nasal Lavage with Amphotericin B on Nasal Polyposis
  Patients in this study had a decrease in the size of their nasal polyps after treatment with a solution of amphotericin B applied to the sinuses twice daily. In 47% of patients, their nasal polyps completely disappeared.
  
  

Patients with CRS usually receive topical antifungal treatment twice daily for at least three months. Most patients begin to experience relief shortly after treatment starts.

Because fungus always exists in the air, patients usually require treatment for a long period of time. Like asthma and allergies, CRS is a chronic disease that requires ongoing treatment. It is important that the patient continue treatment even after they feel better.